Table 2 Top clinical outcome association results among the genotyped SNPs in the ISPC sample

Outcome measure	SNP	CHR	BP	Nearest gene(s)	MA	CA	MAF	C-Frq	A-Frq	Beta/OR	P
%ΔHRSD	rs9328202	6	3887339	RPS25P7	A	C	0.027	0.04	0.02	0.72	6.15E−07
	rs11989215	8	6395909	ANGPT2/MCPH1	G	A	0.360	0.36	0.36	0.24	7.46E−07
	rs16855294	2	169199695	STK39	A	C	0.416	0.60	0.32	−0.24	8.82E−07
	rs7802493	7	138699590	ZC3HAV1L	G	A	0.010	0.03	0	1.14	9.35E−07
	rs10512361	9	110974998	LOC100128657	G	A	0.064	0.18	0	−0.46	2.61E−06
	rs2453488	12	49255208	RND1/DDX23	A	G	0.115	0.27	0.03	−0.37	3.51E−06
	rs1438692	5	148659664	AFAP1L1	A	G	0.491	0.38	0.55	−0.21	4.42E−06
	rs239022	21	17701594	LINC00478	A	G	0.109	0.05	0.14	0.34	4.82E−06
	rs1470108	15	89153744	MIR7-2/MIR3529/MIR1179	A	C	0.216	0.35	0.15	−0.26	6.67E−06
	rs11811628	1	212756393	ATF3	A	G	0.013	0.04	0	0.96	7.50E−06
Response	rs11989215	8	6395909	MCPH1/ANGPT2	G	A	0.360	0.36	0.36	0.62	6.70E−06
	rs1466882	18	4970506	PPIAP14	C	A	0.466	0.52	0.44	1.55	1.23E−05
	rs13015447	2	167377978	SCN7A	A	C	0.443	0.63	0.35	1.57	1.34E−05
	rs2377898	18	8730053	SOGA2	A	G	0.456	0.47	0.45	0.65	1.34E−05
	rs17220479	6	32940815	BRD2	A	G	0.055	0.02	0.07	0.34	1.42E−05
	rs16871297	6	32950217	BRD2	G	A	0.055	0.02	0.07	0.34	1.42E−05
	rs12729349	1	65570028	MRPS21P1	A	G	0.135	0.08	0.16	0.52	2.02E−05
	rs2511398	11	93684809	HPRTP4	G	A	0.433	0.56	0.37	1.51	2.28E−05
	rs2218603	2	167472743	SCN7A	A	G	0.420	0.54	0.36	1.54	3.28E−05
	rs1596996	2	167453461	SCN7A	A	G	0.452	0.59	0.38	1.53	3.63E−05

Abbreviations: A-Frq, frequency of MA in Asian subset; Beta/OR, regression parameter estimates (beta) for SNP effect on quantitative trait outcome or odds ratio (OR) estimate for SNP effect on binary outcome; CA, common allele; C-Frq, frequency of MA in Caucasian subset; HRSD, Hamilton Rating Scale for Depression; ISPC, International SSRI Pharmacogenomics Consortium; MA, minor allele; MAF, minor allele frequency; SNP, single-nucleotide polymorphism.

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