Table 1 MGluR–eEf2–AMPAR pathway predicting alcohol use behavior in the DNHS and GTP

From: Frequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathways

Gene/pathway

Number of SNPs

LD blocks

Empirical P-value

Detroit Neighborhood Health Study (outcome: drinking days per month)

 Gene-based sets

GRM1

15

3

0.009

EIF4E

8

2

0.019

MTOR

15

3

0.039

CAMK2A

13

6

0.039

EEF2

4

1

0.050

HOMER1

31

2

0.128

GRIA1

9

2

0.198

EEF2K

19

4

0.336

HOMER2

38

5

0.366

GRIA4

13

2

0.386

GRM5

38

2

0.505

ARC

3

1

0.755

 Pathway-based set

MGluR–eEf2–AMPAR

206

7

0.009

Grady Trauma Project (outcome: AUDIT score)

 Gene-based sets

GRM1

14

2

0.052

EIF4E

7

2

0.999

MTOR

13

3

0.294

CAMK2A

10

4

0.999

EEF2

4

1

0.008

HOMER1

20

3

0.999

GRIA1

8

6

0.479

EEF2K

17

4

0.999

HOMER2

34

5

0.155

GRIA4

13

2

0.220

GRM5

31

2

0.485

ARC

3

1

0.999

 Pathway-based set

mGluR–eEf2–AMPAR

174

5

0.089

  1. Abbreviations: DNHS, Detroit Neighborhood Health Study; GTP, Grady Trauma Project; MTOR, mechanistic target of rapamycin; SNP, single-nucleotide polymorphism.
  2. Analyses conducted only on drinkers who self-identified as African American; gene-based and pathway-based tests were conducted in PLINK using set-based analyses with empirical P-values derived from 100 000 permutations. Each analysis was corrected for the number of independent signals (that is, linkage disequilibrium (LD) blocks) within that gene set. Pathway-based tests included all available SNPs within each of the genes included in the mGluR–eEf2–AMPAR pathway, corrected for the number of independent signals (that is, LD blocks) within that pathway set.
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