Figure 4 | Translational Psychiatry

Figure 4

From: The oxytocin system promotes resilience to the effects of neonatal isolation on adult social attachment in female prairie voles

Figure 4

Tactile stimulation activates OT neurons in the PVN. PND6–7 neonates were brushed for 5- min to the anogenital and body region or only handled and killed after 1 h. Representative oxytocin (a and b) and vasopressin (c and d) sections in handled (left) and tactile stimulated (right) animals. White arrows indicate cells double labeled for EGR-1 and OT or AVP. Oxytocin cells are green and EGR-1 nuclei are labeled red. Tactile stimulation induced significant EGR-1 activity in oxytocin, but not vasopressin, neurons (e). Asterisk indicates Student’s t-test, P<0.05. AVP, vasopressin; EGR-1, early growth response factor-1; OT, oxytocin; PVN, paraventricular nucleus.

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