Figure 5 | Translational Psychiatry

Figure 5

From: The oxytocin system promotes resilience to the effects of neonatal isolation on adult social attachment in female prairie voles

Figure 5

MTII buffered against early isolation in females. Voles were treated with the melanocortin agonist MTII for the first week of the two-week isolation. Females displayed slowed weight gain for the first week of life, but accelerated weight gain when the drug was off-board (a). MTII treatment significantly reduced weights on PND2 (P=0.012), 3 (P=0.032) and 5 (P=0.036). Neonatal MTII treatment facilitated female pair bonding after a 6h non-mated cohabitation (b). Asterisk indicates t-test (a) or Wilcoxon test (b), P<0.05. MTII, melanotan-II; PND, postnatal day.

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