Figure 3
Rapgef6 deletion impairs hippocampal neural activation during fear conditioning. (a) Dentate gyrus subregion of the hippocampus had reduced cFOS staining in HOM mice compared with WT at baseline (P<0.01) and after fear conditioning (P<0.05). Scale bar, 200 μm for all micrographs. (b) CA3 cFOS staining was increased in WT mice after fear conditioning (P<0.01) but not HET or HOM mice. (c) CA1 cFOS staining was increased in WT mice after fear conditioning (P<0.05) but not HET or HOM mice. *P<0.05, **P<0.01 and ***P<0.001. HET, heterozygous; HOM, homozygous; WT, wild type.
