Figure 5
Spike timing-dependent LTP in cortical input to the LA is enhanced in Rapgef6 knockout mice. (a) Spike timing-dependent LTP at the cortico-LA synapses in slices from WT and HOM mice. Insets show the average of 15 EPSPs recorded in current-clamp mode before and 40 min after induction. (b) Summary of LTP experiments in cortical input to the LA. (c) Evoked cortico-LA EPSCs (average of 15 traces) were recorded sequentially in same neurons at holding potentials −70 mV (bottom) and +40 mV (top) in slices from WT and HOM mice. The NMDA receptor-mediated component of the EPSC was measured at +40 mV at the dashed lines. (d) Summary of the NMDA/AMPA ratio values in slices from WT and HOM mice. Results are shown as mean±s.e.m. EPSP, excitatory postsynaptic potential; HOM, homozygous; LA, lateral nucleus of the amygdala; LTP, long-term potentiation; WT, wild type.
