Table 2 CpG site-specific methylation for significant disorder and adversity types in comparison with No Adversity/No Disorder group

From: Methylation of the leukocyte glucocorticoid receptor gene promoter in adults: associations with early adversity and depressive, anxiety and substance-use disorders

CpG site

Depressive Disorder (n=115)

Anxiety Disorder (n=40)

Past Substance Disorder (n=75)

Emotional Abuse (n=83)

Emotional Neglect (n=88)

Physical Neglect (n=55)

Parental Desertion (n=51)

Mean

7.54**

5.89*

3.89*

6.45*

6.63*

7.19**

6.99**

1

ns

ns

ns

ns

ns

ns

ns

2

ns

ns

ns

ns

ns

ns

ns

3

ns

ns

ns

ns

ns

ns

ns

4

ns

ns

ns

ns

ns

ns

ns

5

ns

ns

ns

ns

ns

ns

ns

6

14.56***

11.75***

7.40**

8.02**

11.60***

8.65**

12.67***

7

3.44t

5.08*

ns

3.59t

3.38t

4.37*

ns

8

ns

ns

ns

3.49t

ns

3.15t

3.34t

9

19.56***

14.05***

8.25**

11.02***

12.35***

12.71***

8.77**

10

6.09*

5.28*

ns

6.06*

5.33*

9.47**

5.18*

11

6.07*

5.59*

3.15t

5.76*

4.84*

6.96**

5.79*

12

21.02***

13.01***

8.64**

14.03***

15.94***

17.66***

11.24***

13

12.48***

12.47***

7.03**

7.76**

8.07**

10.33**

5.68*

  1. Abbreviation: ns, not significant.
  2. Note: All table values represent the F statistic. tP<0.10, *P<0.05, **P<0.01, ***P<0.001.
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