Table 2 Significant association between RAPGEF4 SNPs and cognitive decline
RAPGEF4 SNP | Subjects | Genotype | P-value | ||
|---|---|---|---|---|---|
rs3769219 | TT | TC | CC | ||
CDR 1 | 0 (0%) | 12 (9.4%) | 115 (90.6%) | **0.003 | |
CDR 0.5 | 0 (0%) | 25 (22.5%) | 86 (77.5%) | ||
CDR 0 | 0 (0%) | 45 (24.5%) | 139 (75.5%) | ||
rs3820841 | TT | TC | CC | ||
CDR 1 | 35 (25.4%) | 62 (44.9%) | 41 (29.7%) | **0.001 | |
CDR 0.5 | 37 (22.8%) | 49 (30.2%) | 76 (46.9%) | ||
CDR 0 | 42 (17.7%) | 71 (30.0%) | 124 (52.3%) | ||
rs17746510 | TT | TG | GG | ||
CDR 1 | 48 (34.8%) | 72 (52.2%) | 18 (13.0%) | 0.167 | |
CDR 0 | 93 (39.2%) | 101 (42.6%) | 43 (18.1%) | ||
CDR 1 | 48 (34.8%) | 72 (52.2%) | 18 (13.0%) | *0.036 | |
CDR 0.5 | 62 (38.5%) | 63 (39.1%) | 36 (22.4%) | ||
Combined | |||||
CDR 1 | 48 (34.8%) | 72 (52.2%) | 18 (13.0%) | 0.13 | |
CDR 0.5 | 62 (38.5%) | 63 (39.1%) | 36 (22.4%) | ||
CDR 0 | 93 (39.2%) | 101 (42.6%) | 43 (18.1%) | ||
