Table 4 Results for Pearson's correlation analysis between FA, AD and RD values of the gCC and bCC and SLC6A4 methylation (CpG1, CpG2, CpG3, CpG4 and CpG5) in drug naive MDD patients and healthy controls

From: Association between reduced white matter integrity in the corpus callosum and serotonin transporter gene DNA methylation in medication-naive patients with major depressive disorder

 

SLC6A4 methylation

 

CpG1

CpG2

CpG3

CpG4

CpG5

FA

 MDD patients

     

 gCC

−0.068 (0.702)

−0.195 (0.27)

−0.28 (0.108)

−0.253 (0.15)

−0.132 (0.458)

 bCC

−0.301 (0.084)

−0.255 (0.15)

−0.493 (0.003)a

−0.438 (0.01)b

−0.142 (0.422)

 Healthy controls

     

 gCC

−0.191 (0.192)

−0.17 (0.249)

−0.203 (0.167)

−0.372 (0.009)a

−0.095 (0.519)

 bCC

−0.022 (0.88)

−0.03 (0.840)

−0.042 (0.778)

−0.117 (0.428)

0.013 (0.931)

AD

 MDD patients

     

 gCC

−0.188 (0.288)

−0.315 (0.07)

−0.419 (0.14)

−0.361 (0.036)

−0.301 (0.084)

 bCC

−0.225 (0.2)

−0.252 (0.151)

−0.478 (0.004)a

−0.341 (0.049)

−0.293 (0.092)

 Healthy controls

     

 gCC

0.215 (0.143)

−0.139 (0.345)

−0.101 (0.493)

0.201 (0.170)

−0.042 (0.779)

 bCC

0.024 (0.872)

0.012 (0.938)

0.068 (0.647)

0.082 (0.577)

−0.080 (0.587)

RD

 MDD patients

     

 gCC

0.034 (0.847)

0.124 (0.486)

0.190 (0.282)

0.168 (0.341)

0.042 (0.815)

 bCC

0.237 (0.178)

0.156 (0.378)

0.307 (0.077)

0.294 (0.092)

0.021 (0.907)

 Healthy controls

     

 gCC

0.200 (0.173)

0.153 (0.298)

0.175 (0.234)

0.388 (0.006)a

0.064 (0.664)

 bCC

0.028 (0.850)

0.041 (0.780)

0.022 (0.883)

0.107 (0.470)

−0.041 (0.783)

  1. Abbreviations: AD, axial diffusivity; bCC, body of corpus callosum; FA, fractional anisotropy; gCC, genu of corpus callosum; MDD, major depressive disorder; RD, radial diffusivity; SLC6A4, serotonin transporter gene.
  2. All data are given as coefficient of Pearson's correlation controlling for age (P-value).
  3. aSignificance level for SLC6A4 methylation was corrected for multiple comparisons using Bonferroni's correction; P<0.05/5 (CpG1, CpG2, CpG3, CpG4 and CpG5)=0.01.
  4. bStatistical significance: P=0.01.
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