Figure 1
From: Impact of polygenic schizophrenia-related risk and hippocampal volumes on the onset of psychosis
Linear regression analysis of PSRS and hippocampal volumes. Standardised residuals of the PSRS are adjusted for the first 20 genotypic PCs and the number of SNPs used to calculate the PSRS. Standardised residuals of the mean hippocampal volume are adjusted on each side separately for ICV, age, gender antidepressant intake and CPZ equivalents. Red dashed line, regression line with 95% confidence interval of FEP cohort; blue dot-dashed line, regression line with 95% confidence interval of ARMS cohort. ARMS, at-risk mental state; CPZ, chlorpromazine; FEP, first-episode psychosis; ICV, intracranial volume; PC, principal component; PSRS, Polygenic Schizophrenia-Related Risk Score; SNP, single-nucleotide polymorphism.
