Table 2 Results of linear regression, logistic regression and mediation analyses
From: Impact of polygenic schizophrenia-related risk and hippocampal volumes on the onset of psychosis
Variable | Coefficients | s.e. | Z-value | P-value | 95% CI lower | 95% CI upper |
|---|---|---|---|---|---|---|
Linear regression: ARMS and FEP | ||||||
Intercept | 0.02 | 0.12 | 0.15 | 0.88 | −0.22 | 0.26 |
Hippocampal volumes | −0.42 | 0.15 | −2.83 | 0.01 | −0.72 | −0.12 |
R2=0.11; comparison with null model: χ2=7.75, P=0.01 | ||||||
Linear regression: ARMS only | ||||||
Intercept | −0.20 | 0.16 | −1.29 | 0.21 | −0.52 | 0.12 |
Hippocampal volumes | −0.51 | 0.21 | −2.39 | 0.02 | −0.94 | −0.08 |
R2=0.14; comparison with null model: χ2=5.60, P=0.02 | ||||||
Linear regression: FEP only | ||||||
Intercept | 0.32 | 0.17 | 1.82 | 0.08 | −0.04 | 0.68 |
Hippocampal volumes | −0.41 | 0.20 | −2.03 | 0.05 | −0.83 | 0.01 |
R2=0.14; comparison with null model: χ2=4.11, P=0.04 | ||||||
Logistic regression: ARMS and FEP | ||||||
Intercept | −0.43 | 0.29 | −1.48 | 0.14 | −1.01 | 0.13 |
PSRS | 0.64 | 0.30 | 2.11 | 0.03 | 0.08 | 1.29 |
Hippocampal volumes | 0.59 | 0.37 | 1.60 | 0.11 | −0.11 | 1.36 |
PSRS x hippocampal volumes | −0.14 | 0.37 | −0.39 | 0.70 | −0.88 | 0.60 |
Nagelkerk’se-R2=0.1; c-statistic: 64.4%; comparison with null model: χ2=5.88, P=0.12 | ||||||
Mediation analysis | ||||||
ACME | −0.03 | 0.09 | −0.09 | 0.006 | ||
ADE | 0.14 | 0.03 | 0.02 | 0.27 | ||
Total effect | 0.12 | 0.07 | −0.01 | 0.25 | ||
