Table 1 Single-marker association study in 754 adult ADHD patients and 766 sex-matched unrelated controls considering SNPs in (a) microRNA genes and (b) 3′-UTR of experimentally validated target genes

From: Preliminary evidence for association of genetic variants in pri-miR-34b/c and abnormal miR-34c expression with attention deficit and hyperactivity disorder

 

SNP (risk allele)

Genotypes*

  

Controls N (%)

Cases N (%)

 

Log-additive (22 vs 12 vs 11)

Genotypes 11+12 vs 22

Genotypes 11 vs 12+22

  

11

12

22

11

12

22

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

(a) miRNA

 hsa-miR-128-2

rs9311107 (T)

205 (27.4)

388 (51.9)

155 (20.7)

245 (32.9)

365 (48.9)

136 (18.2)

0.064

1.18 (1.02–1.40)

0.028

1.18 (0.91–1.52)

0.224

1.30 (1.04–1.61)

0.022

 

rs6801590 (A)

367 (49.2)

312 (41.8)

67 (9.0)

402 (53.8)

295 (39.5)

50 (6.7)

0.103

1.19 (1.01–1.39)

0.035

1.36 (0.94–2.00)

0.099

1.20 (0.98–1.47)

0.074

 hsa-let-7a-1/hsa-let-7f-1/hsa-let-7d

rs7865876 (G)

320 (43.0)

352 (47.2)

73 (9.8)

371 (50.3)

308 (41.7)

59 (8.0)

0.017

1.25 (1.06–1.47)

6.2e−03

1.25 (0.87–1.79)

0.222

1.35 (1.10–1.64)

4.7e−03

 

rs8115 (G)

9 (1.2)

148 (19.9)

585 (78.9)

9 (1.2)

184 (24.7)

553 (74.1)

0.091

1.25 (1.00–1.56)

0.048

1.30 (1.02–1.65)

0.032

0.99 (0.39–2.52)

0.991

 hsa-let-7a-3/hsa-mir-4763/hsa-let-7b

rs9616084 (C)

432 (58.0)

275 (37.0)

37 (5.0)

476 (64.0)

236 (31.7)

32 (4.3)

0.065

1.23 (1.02–1.45)

0.030

1.62 (0.72–1.89)

0.538

1.28 (1.04–1.59)

0.019

 

rs6520050 (A)

309 (41.5)

346 (46.5)

89 (12.0)

339 (45.6)

337 (45.4)

67 (9.0)

0.099

1.18 (1.01–1.37)

0.039

1.36 (0.98–1.92)

0.064

1.18 (1.22–1.45)

0.111

 hsa-miR-34b/hsa-miR-34c

rs28690953 (G)

18 (2.4)

178 (23.8)

553 (73.8)

23 (3.1)

231 (31.0)

492 (65.9)

3.9e−03

1.37 (1.12–1.66)

1.6e−03**

1.46 (1.17–1.82)

8.9e−04**

1.29 (0.69–2.41)

0.420

 hsa-miR-371/hsa-miR-372/hsa-miR-373

rs8103186 (C)

33 (4.4)

256 (34.3)

458 (61.3)

46 (6.2)

279 (37.3)

422 (56.5)

0.099

1.20 (1.01–1.43)

0.033

1.22 (0.99–1.50)

0.058

1.42 (0.90–2.25)

0.132

(b) Gene

 MET

rs1621 (G)

65 (8.8)

345 (46.5)

332 (44.7)

93 (12.4)

35 (48.1)

295 (39.5)

0.024

1.23 (1.06–1.44)

8.3e–03

1.24 (1.01–1.52)

0.040

1.48 (1.06–2.07)

0.021

 

rs6566 (G)

212 (28.8)

367 (49.9)

157 (21.3)

245 (32.8)

377 (50.5)

125 (16.7)

0.048

1.19 (1.03–1.39)

0.017

1.35 (1.04–1.75)

0.024

1.20 (0.97–1.39)

0.096

 NOTCH2

rs699779 (T)

561 (75.6)

164 (22.1)

17 (2.3)

596 (79.8)

146 (19.5)

5 (0.7)

0.011

1.31 (1.05–1.64)

0.015

3.45 (1.28–9.09)

7.7e−03

1.27 (1.00–1.64)

0.052

 HMGA2

rs11175982 (T)

31 (4.2)

192 (26.0)

516 (69.8)

31 (4.1)

244 (32.6)

474 (63.3)

0.019

1.23 (1.02–1.47)

0.026

1.34 (1.08–1.67)

7.5e−03

0.99 (0.59–1.64)

0.957

  1. Abbreviations: ADHD, attention deficit hyperactivity disorder; CI, confidence interval; miRNA, microRNA; OR, odds ratio; SNP, single-nucleotide polymorphism; UTR, untranslated region.
  2. *Allele 1 denotes always risk allele and all calculations are performed considering this allele.
  3. **Statistically significant P-values after applying a false discovery rate of 20% (P-value <1.58e−03 for the association tests with SNPs both in the miRNA genes and in the selected target genes).
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