Figure 1 | Translational Psychiatry

Figure 1

From: Antidepressive and BDNF effects of enriched environment treatment across ages in mice lacking BDNF expression through promoter IV

Figure 1

(a) Research design. Male and female wild type (WT) and KIV mice received 2 months of enriched environment treatment (EET: red arrows) or standard condition treatment (SCT: blue arrows) from birth (early-life development: ED), 2 months (young adult: YA) or 12 months of age (old adult: OA), then received 1 month of SCT. Depression-like behavior and brain-derived neurotrophic factor (BDNF) levels were measured after EET (test 1: T1) and consequent SCT (test 2: T2). (b–e) Age and gender effects of deficiency of promoter IV-driven BDNF on total activity (b); distance moved (c); and time in center (d) in the open-field test, and immobility time in the tail-suspension test (e). Results from KIV-SCT mice (male: left; female: right) at T1 are shown as % WT-SCT. Asterisks on the columns show a significant difference between WT and KIV mice. KIV, knock-in BDNF-promoter IV; SCT, standard condition treatment; WT, wild-type. *P<0.05, **P<0.01, ***P<0.005. N=12–16.

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