Table 3 Odds ratio (95% confidence interval) for the cross-sectional association between serum IGF-1 and depression symptoms: the English Longitudinal Study of Ageing, 2008

From: Insulin-like growth factor 1 and risk of depression in older people: the English Longitudinal Study of Ageing

 

IGF-1 quintile (range) a

P-value for linearity

P-value for quadratic

 

1

2

3

4

5

  
 

(2–11)

(12–14)

(15–16)

(17–20)

(21–65)

  

Women (analytical sample)

 Adjustments

Age (3311)

1 (ref)

0.76 (0.58, 0.97)

0.69 (0.50, 0.93)

0.68 (0.52, 0.90)

0.91 (0.68, 1.22)

0.027

0.009

Age, anthropometric measuresb (3181)

1

0.79 (0.61, 1.02)

0.74 (0.54, 1.01)

0.72 (0.54, 0.95)

0.96 (0.71, 1.30)

0.061

0.037

Age, co-morbiditiesc (3308)

1

0.75 (0.58, 0.96)

0.68 (0.50, 0.92)

0.69 (0.52, 0.91)

0.89 (0.66, 1.19)

0.031

0.012

Age, psychosocial factorsd (3162)

1

0.81 (0.62, 1.06)

0.79 (0.57, 1.09)

0.73 (0.55, 0.98)

0.96 (0.70, 1.30)

0.494

0.026

Age, behavioural factorse (2920)

1

0.77 (0.58, 1.02)

0.76 (0.55, 1.06)

0.76 (0.56, 1.02)

0.91 (0.66, 1.25)

0.08

0.078

Multiply adjusted (2691)

1

0.86 (0.63, 1.16)

0.9 (0.63, 1.29)

0.85 (0.62, 1.29)

1 (0.71, 1.41)

0.756

0.199

Men (analytical sample)

 Adjustments

Age (2706)

1 (ref)

0.75 (0.49, 1.16)

0.56 (0.33, 0.95)

0.66 (0.43, 1.02)

1.12 (0.74, 1.69)

0.008

0.004

Age, anthropometric measuresb (2627)

1

0.85 (0.54, 1.34)

0.62 (0.35, 1.09)

0.79 (0.50, 1.25)

1.26 (0.81, 1.96)

0.037

0.011

Age, co-morbiditiesc (2696)

1

0.76 (0.49, 1.18)

0.58 (0.34, 0.98)

0.64 (0.41, 0.99)

1.11 (0.73, 1.68)

0.009

0.003

Age, psychosocial factorsd (2592)

1

0.85 (0.54, 1.34)

0.61 (0.35, 1.06)

0.75 (0.47, 1.19)

1.3 (0.90, 2.16)

0.015

0.045

Age, behavioural factorse (2377)

1

0.68 (0.40, 1.16)

0.57 (0.31, 1.06)

0.71 (0.43, 1.18)

1.32 (0.83, 2.12)

<0.001

0.052

Multiply adjusted (2277)

1

0.84 (0.47, 1.50)

0.63 (0.32, 1.24)

0.84 (0.48, 1.47)

1.54 (0.90, 2.64)

0.006

0.153

  1. Abbreviations: BMI, body mass index; IGF-1, insulin-like growth factor 1.
  2. aIGF-1 units are nmol l−1.
  3. bBMI, height.
  4. cCancer, diabetes, cardiovascular disease.
  5. dOwn wealth quintile per benefit unit (unit is a couple or single person along with their dependent children), education level.
  6. eAlcohol consumption, smoking, physical activity.
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