Table 3 Results from the self-controlled case series analyses
IRR | 95% CI | P-value | |
|---|---|---|---|
Incident psychotic episode (n=103) | |||
Period with MPH treatment | 0.98 | 0.52–1.86 | 0.95 |
Pre-risk period included | |||
90 Days before first MPH treatment | 4.64 | 2.17–9.92 | <0.01 |
Period with MPH treatment | 1.02 | 0.53–1.97 | 0.95 |
Sensitivity analyses | |||
6-Month age band (n=103) | |||
90 Days before first MPH treatment | 3.91 | 1.85–8.28 | <0.01 |
Period with MPH treatment | 0.84 | 0.46–1.55 | 0.58 |
Patients with >10 weeks' MPH exposure (n=82) | |||
90 Days before first MPH treatment | 4.38 | 1.77–10.87 | <0.01 |
Period with MPH treatment | 1.07 | 0.55–2.08 | 0.85 |
Censor by antidepressants/antipsychotics (n=102) | |||
90 Days before first MPH treatment | 6.67 | 2.84–15.66 | <0.01 |
Period with MPH treatment | 0.92 | 0.40–2.13 | 0.84 |
Remove patients with substance dependence (n=87) | |||
90 Days before first MPH treatment | 5.01 | 2.32–10.81 | <0.01 |
Period with MPH treatment | 0.89 | 0.44–1.78 | 0.74 |
Remove hallucination cases (n=83) | |||
90 Days before first MPH treatment | 3.37 | 1.22–9.32 | 0.02 |
Period with MPH treatment | 1.11 | 0.53–2.31 | 0.79 |
Remove cases with event on the first day of treatment (n=102) | |||
90 Days before first MPH treatment | 4.04 | 1.82–8.95 | <0.01 |
Period with MPH treatment | 0.99 | 0.51–1.92 | 0.66 |
Washout period: 7 days before the first treatment (n=90) | |||
90 Days before first MPH treatment | 3.90 | 1.69–9.01 | <0.01 |
Period with MPH treatment | 1.01 | 0.53–1.94 | 0.97 |
Washout period: 14 days before the first treatment (n=90) | |||
90 Days before first MPH treatment | 4.26 | 1.84–9.86 | <0.01 |
Period with MPH treatment | 1.01 | 0.53–1.94 | 0.98 |
Washout period: 21 days before the first treatment (n=89) | |||
90 Days before first MPH treatment | 3.96 | 1.62–9.69 | <0.01 |
Period with MPH treatment | 1.01 | 0.53–1.95 | 0.97 |
Start of observation at 1 January 2001, the sixth birthday of the patient, the first observed date of ADHD diagnosis or the first date of MPH treatment, whichever occurred last (n=79) | |||
90 Days before first MPH treatment | 3.59 | 1.13–11.4 | <0.01 |
Period with MPH treatment | 1.26 | 0.61–2.59 | 0.53 |
60-Day pre-exposure period | |||
60 Days before first MPH treatment | 5.99 | 2.71–13.22 | <0.01 |
Period with MPH treatment | 1.01 | 0.53–1.95 | 0.97 |
30-Day pre-exposure period | |||
30 Days before first MPH treatment | 5.21 | 1.83–14.81 | <0.01 |
Period with MPH treatment | 0.94 | 0.49–1.81 | 0.86 |
