Figure 5 | Translational Psychiatry

Figure 5

From: IP3 accumulation and/or inositol depletion: two downstream lithium’s effects that may mediate its behavioral and cellular changes

Figure 5

Suggested mechanisms of Li-induced behavior and enhanced autophagy: 1—according to the results in the SMIT1 KO mice; 2—according to the results in the IMPA1 KO mice; 3—according to de Bartolomeis et al.;72 4—according to the results in IP3-treated mice; 5—a reasonable assumption; 6—according to Vicencio et al.;49 and 7—according to Kara et al.47 IP, inositol phosphate; KO, knockout; Li, lithium; PI, phosphatidylinositol.

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