Figure 1 | Translational Psychiatry

Figure 1

From: Newer insights into the role of miRNA a tiny genetic tool in psychiatric disorders: focus on post-traumatic stress disorder

Figure 1

microRNAs (miRs) biogenesis and function. miRs are transcribed by RNA polymerase II or III as pri-miR, and are processed in the nucleus by Drosha into pre-miRs. The pre-miR, is exported to the cytoplasm by exportin-5 and further cleaved in a complex composed of Dicer and trans-activation response RNA-binding protein. The functional strand of mature miR is incorporated into the RNA-induced silencing complex (RISC). As a part of this complex, the mature miR regulates gene expression by binding to partially complementary sequences in the 3′-untranslated regions (3′UTRs) of target mRNAs, leading to transcriptional repression and transcriptional activation.

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