Table 2 miR implication in stress and depression results from clinical and preclinical models
Species | Effect/tissue | miR | Reference |
|---|---|---|---|
Human | Blood | has-miR-130b, miR 505, miR-29b-2, miR-26b, miR22, miR26a, miR664, miR-494, miR629, miR106b, miR103, miR-191, miR128, miR502-3p, miR 374b, miR-132, miR30d, miR-500, miR-770-5p, miR-589, miR-183, miR-574-3p, miR-140-3p, miR-335, miR-361-5 phas-let-7g, has-let-7d, has-let-7e, has-miR-34c-5p, has-let-7f | Bocchio-Chiavetto et al.50 |
Human | Blood | Has- miR-107, miR-133a, miR-148a, miR-200c, miR381, miR-425-3p,miR-494, miR-517b, miR-579, miR-589, miR-636, miR-652, miR-941, miR-1243 | Belzeaux et al.51 |
Human | Plasma | miR-144-5p | Wang et al.52 |
Human | Blood | miR-34b-5p and miR-34c-5p | Sun et al.53 |
Human | Blood | miR-182, miR-132 and miR-182 | Li et al.54 |
Human | Blood | miR-26b, miR-1972, miR-4485, miR-4498 and miR-4743 | Fan HM et al.55 |
Human | Blood/Brain | miR-135 | Issler et al.56 |
Human | Blood | miR-320, miR-451, miR-17-5p, miR-223-3p | Camkurt et al.57 |
Human | Post-mortem prefrontal cortex brain tissue/ depressant patient blood | miR-1202 | Lopez et al.58 |
Human/postmortem brain studies | Prefrontal cortex | has- miR-10a, miR-20a, miR-20b, miR-27a, miR-33a,miR-137, miR-142-3p, miR-142-5p, miR-148b, miR-155, miR-190miR-376a | Smalheiser et al.59 |
Human | Blood and brain | miR135 | Issler et al.56 |
Rat | Serum | miR-16 | Zurawek et al.60 |
Rat | Immobilization stress/ hippocampus CA1, amygdala | miR-132, miR-134, miR-183, let-7a-a, miT-9-1, miR-124a-1 | Meerson et al.61 |
Rat | Unpredictable chronic mild stress/hippocampus | miR-125a, miR-298, miR-130b, miR-135a, miR-323, miR-503, miR-15b, miR-532 miR-7a, miR-212, miR-124, miR-139, miR-182 | Cao et al.34 |
Rat | Inescapable shock/frontal cortex | mmu-miR-184, Mmu-miR-197, mmu-miR-107, mmu-miR-329, mmu-miR-125a-5p, mmu-miR-872, mmu-miR-181c, mmu-miR-18a, mmu-miR-29b, mmu-let-7a. Rno-let-7e, rno-miR-20a | Smalheiser et al.62 |
Mice | Unpredictable mild stress/frontal lobe and hippocampus | miR-132, miR-18a, miR-134, miR-124a miR-18a | Pan and Liu63 |
Mice | Restraint stress/ frontal cortex | miR-9, miR26a/b, miR-29b,miR-30b, miR-30b/c, miR-30c, miR-30e, miR125a, miR-126-3p,miR-129-3p, miR-207, miR-212, miR351, miR423, miR-487b, miR-494, miR-690, miR-691, miR-709, miR711 and let-7a-e let-7 | Rinaldi et al.64 |
Mice | Stressed/hypothalamus | miR-18, miR-12a | Shimizu et al.65 |
