Figure 2
Rescue of impaired fear extinction induces a select transcriptional response in the medial prefrontal cortex (mPFC) and amygdala. (a) Scheme illustrating experimental paradigm. Mice were subjected to ‘normal’ 0.6 mA fear conditioning (Cond.) in context A and fear extinction (Ext training in context B). All groups were conditioned on control diet (Ctl) before mice were subjected to dietary zinc restriction (ZnR) for 14 days till Ext. (b) Heatmap depicting differentially expressed genes in the mPFC (491) and amygdala (52) determined using microarray analysis between non-extinguishing Ctl diet-fed mice and extinguishing ZnR-fed mice. Each line depicts a differentially regulated gene; each row depicts the gene expression in each animal. Blue and red indicate low and high levels of expression, respectively. (c) Histogram showing the biological process to which the differentially regulated genes belong (orange, number of differentially regulated genes per biological process; green, significance of enrichment).
