Figure 1

A visual depiction of the parent study and the current sub-study to explicate the analyses conducted. Grey ‘X’ markings depict where only serum samples were available for the analysis (inflammatory markers), and black ‘X’ markings indicate that both serum and whole bloods were available for the analysis (inflammatory markers and DNA methylation). The perforated rectangles indicate the longitudinal analyses conducted (where possible), and the perforated oval indicates the conduct of cross-sectional analysis.