Table 4 Results of DNA methylation cross-sectional ANCOVA analyses

From: Preliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed women

Promoter region	Control		Yoga		Main effect	Effect with covariates (age and WtHR)
	Mean (s.d.)	n	Mean (s.d.)	n	Yoga vs control	Yoga vs control	Covariates
IL6 ₁
CpG 1	0.898 (0.024)	13	0.921 (0.021)	9	F(1,20)=5.29, P=0.032*, η_ρ²=0.21	F(3,18)=4.30, P=0.053^†, η_ρ²=0.19	Age η_ρ²=0.11, WtHR η_ρ²=0.02
CpG 2/3	0.931 (0.013)	10	0.924 (0.019)	8	F(1,16)=0.768, P=0.394, η_ρ²=0.05	F(3,14)=1.12, P=0.307, η_ρ²=0.07	Age η_ρ²=0.07, WtHR η_ρ²=0.04
CpG 4/5/6	0.928 (0.016)	14	0.933 (0.009)	9	F(1,21)=0.59, P=0.452, η_ρ²=0.03	F(3,19)=0.27, P=0.609, η_ρ²=0.01	Age η_ρ²=0.02, WtHR η_ρ²=0.11
Mean	0.853 (0.246)	14	0.926 (0.011)	9	F(1,21)=0.78, P=0.387, η_ρ²=0.04	F(3,19)=0.72, P=0.406, η_ρ²=0.04	Age η_ρ²=0.10, WtHR η_ρ²=0.00
IL6 ₂
CpG 1	0.035 (0.009)	15	0.037 (0.010)	11	F(1,24)=0.24, P=0.626, η_ρ²=0.01	F(3,22)=0.14, P=0.717, η_ρ²=0.00	Age η_ρ²=0.02, WtHR η_ρ²=0.04
CpG 2	0.006 (0.009)	15	0.003 (0.005)	11	F(1,24)=0.91, P=0.349, η_ρ²=0.04	F(3,22)=1.22, P=0.281, η_ρ²=0.05	Age η_ρ²=0.05, WtHR η_ρ²=0.04
CpG 4/5/6	0.033(0.011)	15	0.034 (0.009)	11	F(1,24)=0.04, P=0.852, η_ρ²=0.00	F(3,22)=0.01, P=0.931, η_ρ²=0.00	Age η_ρ²=0.04, WtHR η_ρ²=0.00
CpG 7/8	0.078(0.020)	15	0.084 (0.015)	11	F(1,24)=0.56, P=0.463, η_ρ²=0.02	F(3,22)=0.44, P=0.515, η_ρ²=0.02	Age η_ρ²=0.00, WtHR η_ρ²=0.01
Mean	0.038 (0.008)	15	0.040 (0.007)	11	F(1,24)=0.13, P=0.720, η_ρ²=0.01	F(1,22)=0.05, P=0.824, η_ρ²=0.00	Age η_ρ²=0.04, WtHR η_ρ²=0.03
TNF
CpG 1	0.829 (0.079)	13	0.748 (0.108)	6	F(1,17)=3.45, P=0.081^†, η_ρ²=0.17	F(3,15)=2.32, P=0.148, η_ρ²=0.13	Age η_ρ²=0.04, WtHR η_ρ²=0.00
CpG 2	0.814 (0.079)	13	0.738 (0.086)	8	F(1,19)=4.30, P=0.052^†, η_ρ²=0.19	F(3,17)=4.56, P=0.049*, η_ρ²=0.21	Age η_ρ²=0.00, WtHR η_ρ²=0.04
CpG 4/5/6	0.142 (0.074)	13	0.106 (0.043)	9	F(1,20)=1.69, P=0.208, η_ρ²=0.09	F(3,18)=2.51, P=0.131, η_ρ²=0.12	Age η_ρ²=0.00, WtHR η_ρ²=0.20*
CpG 8	0.231 (0.096)	14	0.210 (0.091)	10	F(1,22)=0.28, P=0.599, η_ρ²=0.01	F(3,20)=0.33, P=0.573, η_ρ²=0.02	Age η_ρ²=0.02, WtHR η_ρ²=0.02
CpG 9	0.089 (0.050)	13	0.075 (0.030)	10	F(1,21)=0.63, P=0.437, η_ρ²=0.03	F(3,19)=0.57, P=0.458, η_ρ²=0.03	Age η_ρ²=0.01, WtHR η_ρ²=0.00
CpG 12	0.087 (0.060)	13	0.073 (0.031)	8	F(1,19)=0.39, P=0.537, η_ρ²=0.02	F(3,17)=0.49, P=0.495, η_ρ²=0.03	Age η_ρ²=0.17, WtHR η_ρ²=0.05
Mean	0.367 (0.048)	15	0.322 (0.046)	11	F(1,24) =5.68, P=0.025*, η_ρ²=0.19	F(3,22)=6.16, P=0.021*, η_ρ²=0.22	Age η_ρ²=0.00, WtHR η_ρ²=0.09
CRP
CpG 1	0.875 (0.048)	12	0.885 (0.031)	10	F(1,20)=0.32, P=0.579, η_ρ²=0.02	F(3,18)=0.18, P=0.675, η_ρ²=0.01	Age η_ρ²=0.12, WtHR η_ρ²=0.00
CpG 2	0.733 (0.064)	12	0.740 (0.058)	10	F(1,20)=0.06, P=0.803, η_ρ²=0.00	F(3,18)=0.01, P=0.937, η_ρ²=0.00	Age η_ρ²=0.33, WtHR η_ρ²=0.22
CpG 4	0.726 (0.074)	12	0.715 (0.051)	10	F(1,20)=0.15, P=0.701, η_ρ²=0.01	F(3,18)=0.39, P=0.539, η_ρ²=0.02	Age η_ρ²=0.14, WtHR η_ρ²=0.07
Mean	0.717 (0.220)	13	0.709 (0.237)	11	F(1,22)=0.01, P=0.934, η_ρ²=0.00	F(3,20)=0.01, P=0.908, η_ρ²=0.00	Age η_ρ²=0.01, WtHR η_ρ²=0.02
LINE-1
CpG 1	0.693 (0.020)	15	0.692 (0.017)	11	F(1,24)=0.00, P=0.958, η_ρ²=0.00	F(3,22)=0.00, P=0.974, η_ρ²=0.00	Age η_ρ²=0.06, WtHR η_ρ²=0.07
CpG 2	0.721 (0.014)	15	0.724 (0.009)	11	F(1,24)=0.32, P=0.577, η_ρ²=0.01	F(3,22)=0.25, P=0.626, η_ρ²=0.01	Age η_ρ²=0.00, WtHR η_ρ²=0.04
CpG 3	0.607 (0.012)	15	0.605 (0.015)	11	F(1,24)=0.20, P=0.662, η_ρ²=0.01	F(3,22)=0.24, P=0.632, η_ρ²=0.01	Age η_ρ²=0.00, WtHR η_ρ²=0.04
Mean	0.674 (0.014)	15	0.674 (0.012)	11	F(1,24)=0.00, P=0.997, η_ρ²=0.00	F(1,22)=0.00, P=0.982, η_ρ²=0.00	Age η_ρ²=0.02, WtHR η_ρ²=0.07

Abbreviations: ANCOVA, analysis of covariance; CRP, C-reactive protein; IL-6, interleukin-6; TNF, tumour necrosis factor.
*P<0.05; ^†P<0.10 (two-tailed tests). η_ρ²=partial eta squared.

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Table 4 Results of DNA methylation cross-sectional ANCOVA analyses

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