Table 1 The relationship between ADCYAP1R1 expression and rs2267735 genotype, estradiol and PTSD symptoms in whole-blood mRNA from study participants
From: Functional evaluation of a PTSD-associated genetic variant: estradiol regulation and ADCYAP1R1
A | N | High ADCYAP1R1 expression | Low ADCYAP1R1 expression |
|---|---|---|---|
All genotypes | |||
Low serum estradiol (range : 5.70–32.74 pg ml−1) | 48 | 39.6% (N=19) | 60.4% (N=29) |
High serum estradiol (range: 33.84–528.35 pg ml−1) | 47 | 61.7% (N=29) | 38.3% (N=18) |
Pearson χ2, P=0.031 | |||
B | N | Mean ADCYAP1R1 ΔCt | s.d. |
Lower quartile of estradiol (E2) | |||
rs2267735 genotype | |||
GG or GC (E2 range: 5.70–14.75 pg ml−1) | 14 | 20.86 | 1.61 |
CC (E2 range: 5.70–15.0 pg ml−1) | 10 | 22.02 | 0.86 |
Two-tailed t-test, P=0.049 | |||
C | N | High ADCYAP1R1 expression | Low ADCYAP1R1 expression |
CC genotypes only | |||
Low serum estradiol (range: 5.70–32.74 pg ml−1) | 23 | 30.4% (N=7) | 69.6% (N=16) |
High serum estradiol (range: 41.91–269.31 pg ml−1) | 19 | 63.2% (N=12) | 36.8% (N=7) |
Pearson χ2, P=0.034 | |||
D | N | Mean PTSD symptoms | s.d. |
High ADCYAP1R1 expression | 48 | 7.97 | 9.22 |
Low ADCYAP1R1 expression | 47 | 12.38 | 9.77 |
Two-tailed t-test, P=0.026 | |||
