Table 3 The interaction effect of group by composite cognitive score and neuroanatomical measures for each molecular parameter

From: Brain structure and intragenic DNA methylation are correlated, and predict executive dysfunction in fragile X premutation females

Outcome variables

F (ηp2)

 

CGG

AR

FMR1 mRNA

CpG 1

CpG 2

CpG 6/7

CpG 8/9

CpG 10–12

Prosaccade response time

0.235 (0.014)

3.038 (0.160)

1.418 (0.081)

0.416 (0.025)

0.983 (0.058)

2.535 (0.133)

0.923 (0.053)

0.556 (0.033)

Prosaccade error score

15.533 (0.485)

0.218 (0.013)

1.803 (0.101)

0.185 (0.011)

0.691 (0.041)

1.703 (0.094)

2.108 (0.113)

0.855 (0.049)

Executive function score

6.620 (0.286)

1.914 (0.107)

1.077 (0.063)

0.017 (0.001)

1.168 (0.068)

1.905 (0.104)

1.309 (0.074)

2.394 (0.127)

White matter hypointensities

0.421 (0.025)

1.905 (0.104)

2.224 (0.122)

2.125 (0.114)

0.595 (0.036)

3.080 (0.157)

1.664 (0.092)

0.580 (0.034)

Left middle frontal gyrus

1.692 (0.093)

1.012 (0.059)

0.386 (0.024)

0.032 (0.002)

3.241 (0.168)

8.131 (0.330)

6.061 (0.269)

6.088 (0.270)

Right middle frontal gyrus

0.374 (0.022)

0.549 (0.033)

1.069 (0.063)

0.253 (0.015)

0.118 (0.007)

1.405 (0.078)

5.600 (0.253)

1.803 (0.099)

Left superior frontal gyrus

0.101 (0.006)

0.319 (0.020)

1.294 (0.075)

0.701 (0.041)

1.050 (0.062)

3.033 (0.155)

3.532 (0.176)

2.678 (0.140)

Right superior frontal gyrus

0.072 (0.004)

0.767 (0.046)

0.853 (0.051)

0.797 (0.046)

0.896 (0.053)

3.497 (0.175)

4.596 (0.218)

1.790 (0.098)

Left inferior parietal gyrus

0.035 (0.002)

0.855 (0.051)

1.134 (0.066)

0.835 (0.048)

0.129 (0.008)

5.031 (0.234)

2.717 (0.141)

1.604 (0.089)

Right inferior parietal gyrus

0.045 (0.003)

0.477 (0.029)

1.614 (0.092)

0.177 (0.011)

0.059 (0.004)

0.372 (0.022)

0.120 (0.007)

0.303 (0.018)

  1. Abbreviations: ηp2, partial eta squared; AR, activation ratio; F, F-test statistic; FMR1, Fragile X mental retardation 1.
  2. Note: Figures in bold indicate that P<0.05.