Table 2 Comparison of phospho-GluA1-Ser831 and phospho-GluA1-Ser845 levels variation in the middle temporal neocortex, amygdala and head of the hippocampus according to dexamethasone treatment

From: A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system

Variables

All cases, n=31, mean (s.e.)

No dexamethasone, n=11, mean (s.e.)

Dexamethasone, n=20, Mean (s.e.)

P-value

Middle temporal neocortex

 P-GluA1-Ser831

118.6 (3.2)

126.9 (6.3)

114.3 (3.2)

0.06a

 P-GluA1-Ser845

112.4 (3.0)

103.1 (4.1)

117.3 (3.6)

0.02b

Amygdala

 P-GluA1-Ser831

109.3 (3.0)

122.8 (4.6)

101.9 (2.8)

0.0003c

 P-GluA1-Ser845

108.1 (3.3)

108.2 (6.0)

108.0 (4.1)

0.98

Hippocampus

 P-GluA1-Ser831

97.0 (3.7)

105.2 (7.2)

92.5 (4.0)

0.10d

 P-GluA1-Ser845

104.2 (3.6)

100.5 (7.8)

106.3 (3.7)

0.46

  1. aNon-significant trend of 12.6% decrease in the neocortex levels of P-GluA1-Ser831;
  2. bNon-significant trend of 14.2% decrease in the neocortex levels of P-GluA1-Ser845;
  3. cSignificant decrease of 20.9% in the amygdala levels of P-GluA1-Ser831;
  4. dNon-significant trend of 12.7% decrease in the hippocampus levels of P-GluA1-Ser831.
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