Figure 1 | Translational Psychiatry

Figure 1

From: The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies

Figure 1

Schematic model for the potential pleiotropic effects of a shared gene locus that is associated with mood disorders and cardiometabolic diseases.5, 6, 26, 70, 71, 75 The distal and proximal factors are obtained from the literature, and the World Health Organization (WHO) often uses the classification. Distal factors refer to those factors that require an intermediate factor to cause diseases, while proximal factors can directly cause diseases. The red bold lines represent the pleiotropic effect of a genetic locus on cardiometabolic diseases and associated risk factors, psychiatric morbidity, i.e.mood disorders and pharmacological treatment response in MDD and BPD. The bi-directional arrows indicate bidirectional epidemiological relationships between the cardiometabolic diseases and mood disorders. BPD, bipolar disorder; MDD, major depressive disorder.

Back to article page