Figure 1
From: Default mode network deactivation during emotion processing predicts early antidepressant response
Emotion-processing-related brain activity assessed with the EDT and 7T fMRI. Figure exhibits contrast of EDT versus ODT (a) and EDT versus baseline (b) BOLD response, which was used to elucidate emotion-processing-related brain activity. Performance of the EDT results in activation of emotion- and face-processing regions34, 35, 36, 37 and deactivation of regions involved in the DMN,52 as was the case in our group of MDD patients (Table 1). Performance of the EDT specifically elucidates attentional control as a top–down control aspect of emotion processing.31, 32, 33 T-threshold for P⩽0.001 uncorrected, voxel-level=3.53 (a, b); P⩽0.05 FWE-corrected, cluster-level k=443 (a), 57639 (b). BOLD, blood-oxygen-level-dependent; DMN, default mode network; EDT, emotion discrimination task (test condition); fMRI, functional magnetic resonance imaging; FWE, family-wise error; ODT, object discrimination task (control condition); MDD, major depressive disorder.
