Figure 2
From: Default mode network deactivation during emotion processing predicts early antidepressant response
Deactivation in the precuneus and PCC correlates with early response. Regression analysis revealed a cluster of deactivation with peak in the precuneus and stretching to the PCC isolated using the contrast EDT versus ODT that correlated positively (P<0.001, FWE-corrected, cluster-level) with antidepressant response assessed as HAMD reduction after 2 weeks of treatment. The precuneus and PCC are considered central components of the DMN.51 Therefore, across our group of MDD patients, the stronger the deactivation of the DMN during emotion processing was at baseline, the more HAMD decreased after 2 weeks of Escitalopram treatment. T-threshold for P⩽0.001 uncorrected, voxel-level=3.65; P⩽0.05 FWE-corrected, cluster-level k=233. DMN, default mode network; EDT, emotion discrimination task (test condition); FWE, family-wise error; HAMD, Hamilton Depression Rating Scale; MDD, major depressive disorder; ODT, object discrimination task (control condition); PCC, posterior cingulate cortex.
