Table 1 Summary of single marker and haplotype meta-analyses

From: Meta-analysis reveals associations between genetic variation in the 5′ and 3′ regions of Neuregulin-1 and schizophrenia

NRG1 markers/haplotypes

Risk

k

Case/control (family trios)

Meta-analysis

Heterogeneity

    

OR

95% CI

90% CI a

P

Q/ τ2

P

I2

95% PI

Single markers

 rs73235619b,c

G

13

6145/6607 (262)

1.18

0.81, 1.71

0.87, 1.60

0.180

80.6

<0.001

85.1

0.47, 2.94

 rs35753505b,c

C

35

12 708/14 302 (1601)

1.04

0.97, 1.11

0.98, 1.10

0.120

85.4

<0.001

60.2

0.79, 1.36

 rs62510682b,c

G

25

10 791/11 986 (1248)

1.10

1.01, 1.20

1.02, 1.18

0.018

54.3

<0.001

55.8

0.84, 1.44

 rs4281084

A

3

2217/2919

1.03

0.98, 1.08

1.00, 1.06

0.060

0.1

0.96

0.0

0.90, 1.18

 rs6994992b,c

T

27

11 848/14 106 (1097)

1.00

0.96, 1.05

0.97, 1.04

0.440

36

0.09

27.8

0.88, 1.14

 rs113317778b,c

G

10

4586/4935 (1003)

0.81

0.52, 1.25

0.57, 1.15

0.150

146.4

<0.001

93.9

0.17, 3.76

 rs7014762

A

4

2128/2398 (634)

1.05

0.98, 1.12

1.00, 1.10

0.060

0.7

0.87

0.0

0.96, 1.15

 478B14-848 (0)c

-

11

1071/1056 (111)

1.11

1.02, 1.20

—

0.008

12.3

0.27

18.5

0.97, 1.27

 478B14-848 (4)

-

5

1015/894 (463)

0.98

0.74, 1.29

—

0.410

9.3

0.05

57.2

0.54, 1.78

 rs1081062

C

4

2635/2946 (634)

0.99

0.83, 1.19

0.87, 1.14

0.460

3.6

0.31

16.1

0.71, 1.39

 rs776401

C

3

3103/4817

0.97

0.63, 1.48

0.73, 1.29

0.390

10.3

0.006

80.6

0.12, 7.68

 420M9-1395 (0)c

-

10

4777/4567 (111)

1.01

0.81, 1.25

—

0.460

36.5

<0.001

75.4

0.63, 1.63

 420M9-1395 (-2)

-

7

1313/1130 (647)

1.05

0.96, 1.15

—

0.100

3.6

0.73

0.0

0.96, 1.15

 rs3924999

A

16

6725/8551 (725+15bios)

1.02

0.90, 1.16

—

0.370

50.3

<0.001

70.2

0.72, 1.46

 rs2439272

A

5

3003/4106 (111)

0.87

0.61, 1.23

0.67, 1.14

0.170

20.3

<0.001

80.3

0.42, 1.81

 rs2466058

T

4

1863/1784 (111)

1.08

0.67, 1.74

0.76, 1.54

0.330

8.1

0.05

62.8

0.34, 3.39

 rs2954041

T

7

3906/5527 (246)

1.21

0.97, 1.52

1.02, 1.45

0.038

10.6

0.10

43.3

0.76, 1.94

 rs6988339

G

4

1113/2104 (111)

0.99

0.72, 1.37

0.78, 1.26

0.470

9.6

0.023

68.7

0.43, 2.27

 rs764059

G

3

910/857 (111)

0.97

0.74, 1.28

0.81, 1.17

0.350

1.0

0.60

0.0

0.43, 2.18

 rs74942016

T

3

1380/2222

1.11

0.77, 1.61

0.87, 1.43

0.170

0.3

0.87

0.0

0.38, 3.29

 rs10503929

T

6

3399/4635 (151)

1.54

0.65, 3.65

0.78, 3.03

0.128

60.9

<0.001

91.8

0.36, 6.53

 rs4733376

G

4

1843/2606 (111)

1.12

0.88, 1.42

0.94, 1.34

0.110

4.2

0.25

27.8

0.69, 1.81

Haplotypes

 Five-marker HapICE haplotype

GCGTG

5

2501/2283 (111)

1.16

0.91, 1.48

—

0.180

0.02d

0.07

53.1

0.67, 1.99

 Seven-marker HapICE haplotype

GCGTG00

5

2501/2283 (111)

1.29

0.77, 2.13

—

0.250

0.12d

0.01

68.5

0.37, 4.39

  1. Abbreviations: CI, confidence interval; HapICE, haplotype in the Icelandic population; OR, odds ratio; PI, prediction interval.
  2. SNP8NRG221132=rs73235619, SNP8NRG221533=rs35753505, SNP8NRG241930=rs62510682, SNP8NRG243177=rs6994992, SNP8NRG433E1006=rs113317778. P<0.05 are bold faced.
  3. a90% CI for one-sided test.
  4. bMarkers forming five-marker HapICE haplotype.
  5. cMarkers forming seven-marker HapICE haplotype.
  6. dTau squared (τ2) values.
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