Figure 4
Distribution of plasma levels of MCP-4 over a circadian interval for patients with post-traumatic stress disorder (PTSD) and healthy controls. (a) Differences between average log plasma MCP-4 levels in female PTSD patients vs female healthy controls. Error bars are ±s.e.m. P-values for the difference at each hour are shown in d. PTSD Females are greater than healthy control females at every hour and the differences are significant (P⩽0.05). (b) Differences between average log plasma MCP-4 levels in male PTSD patients vs male healthy controls. Error bars are ±s.e.m. P-values for the difference at each hour are shown in d. PTSD males only trend greater than healthy control males at every hour, except in the interval (+9<Z<+12) h, where the differences are significant (P⩽0.05). (c) Differences between average log plasma MCP-4 levels in all PTSD patients vs all healthy controls. Error bars are ±s.e.m. P-values for the difference at each hour are shown in d. All PTSD patients are greater than all healthy controls at every hour and the differences are significant (P⩽0.05). However, this significance is based on preponderance of female PTSD relative to male PTSD patients. (d) Significance of log plasma concentration differences for MCP-4 over circadian time. Vertical axis is log P-value. Red horizontal line marks P=0.05 on a logarithmic scale. Male PTSD (dotted black line); female PTSD (dashed black line); all PTSD (solid black line). Female PTSD patients have a significantly higher MCP-4 expression than female healthy controls. Significance of both genders (M,F) is based on preponderance of female PTSD relative to male PTSD patients.
