Figure 5
Distribution of plasma levels of MIP-1β over a circadian interval for patients with post-traumatic stress disorder (PTSD) and healthy controls (HC). (a) Differences between average log plasma MIP-1β levels in female PTSD patients vs female healthy controls. Error bars are ±s.e.m. P-values for the difference at each hour are shown in d. PTSD Females are greater than healthy control females at every hour and the differences are significant, or trend to being significant at each hour across circadian time. (P⩽0.05). (b) Differences between average log plasma MIP-1β levels in male PTSD patients vs male healthy controls. Error bars are ±s.e.m. P-values for the difference at each hour are shown in d. PTSD males are trend slightly greater than healthy control males at every hour. However, the differences at every hour are not significant across circadian time,(P⩽0.05). Note that healthy control males differ from healthy control females by being intrinsically elevated into levels of MIP-1β comparable to female PTSD patients. (c) Differences between average log plasma MIP-1β levels in all PTSD patients vs all healthy controls. Error bars are ±s.e.m. P-values for the difference at each hour are shown in d. All PTSD patients trend greater than all healthy controls at every hour. However, this trend is based on the contribution from female PTSD patients only. (d) Significance of log plasma concentration differences for MIP-1β over circadian time. Vertical axis is log P-value. Red horizontal line is the same as P=0.05 on a arithmetic scale. Male PTSD (dotted black line); female PTSD (dashed black line); all PTSD (solid black line). Only female PTSD differ significantly from female healthy controls at every hour across circadian time.
