Table 1 Cytokine and chemokine concentrations in plasma samples from PTSD and healthy controls at 0900 hours (pg ml⁻¹)

Analyte	PTSD ^a	HC ^a	P-value^b	Ratio ^c	AUC ^d
GM-CSF	< LLOD	< LLOD	NA	NA	NA
IFN-γ	< LLOD	< LLOD	NA	NA	NA
IL-10	0.79±0.24	0.69±0.32	0.21	1.15±0.60	0.69
IL-12 p70	< LLOD	< LLOD	NA	NA	NA
IL-1β	0.08±0.02	0.18±0.04	0.04	↓ 2.12±0.63	0.71
IL-2	0.15±0.04	0.17±0.05	0.72	0.93±0.38	0.55
IL-6	0.47±0.04	0.77±0.16	0.15	↓ 1.62±0.33	0.74
IL-8	1.67±0.56	1.98±0.59	0.67	0.84±0.37	0.52
TNF-α	2.57±0.41	1.57±0.22	0.03	↑ 1.64±0.34	0.76
Eotaxin	503.45±37.95	496.61±37.29	0.91	1.01±0.11	0.52
Eotaxin-3	6.90±0.55	6.42±0.38	0.58	1.07±0.10	0.63
IP-10	226.06±30.53	149.66±13.37	0.04	↑ 1.51±0.24	0.73
MCP-1	171.11±17.01	207.10±17.49	0.14	0.83±0.11	0.82
MCP-4	298.35±27.00	208.62±23.94	0.01	↑ 1.43±0.20	0.77
MDC	1850.02±155.12	1680.60±167.21	0.40	1.10±0.14	0.61
MIP-1β	65.85±8.12	55.58±4.77	0.36	1.18±0.17	0.66
TARC	85.52±13.86	67.32±10.24	0.30	↑ 1.27±0.28	0.70
MCP1/MCP4	0.61±0.06	1.12±0.18	4E−03	↓ 1.84±0.33	0.84
MCP4/MCP1	1.82±0.19	1.10±0.16	4E−03	↑ 1.66±0.28	0.84

Abbreviations: CSF, cerebrospinal fluid; HC, healthy controls; IFN-γ, interferon γ; IL, interleukin; LLOD, lower limit of detection; NA, not applcable; PTSD, post-traumatic stress disorder; ROC, receiver operation condition; TNF-α, tumor necrosis factor α.
^aAverage±s.e.m., pg ml⁻¹.
^bTwo-tailed t-test.
^c↑PTSD>HC;↓PTSD<HC.
^dArea under the curve (AUC) of the ROC Curve.

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