Figure 1
Effect of increasing MIR137 pathway risk score (P=10−5 level) on neural activity during increasing spatial working memory load (3 dots versus 1 dot), 3 outliers removed (N=83; shown in red), shown alongside overall activation for this contrast in the same group (shown in blue). Cluster 1 (right inferior occipital gyrus and right middle temporal gyrus), top panels; Cluster 2 (medial parietal region) bottom panels. Clusters are significant at P<0.05, FWE-corrected at the cluster level and represent regions where neural activity was greater with increasing risk score. Each 2D axial slice is labeled with an x-coordinate (MNI space). Clusters are rendered on the ‘ch256’ brain template using MRIcroGL (http://www.mccauslandcenter.sc.edu/mricrogl/). Additional editing of figure (for example, changing the size/resolution) performed using MS Paint and/or Paint.NET v3.5.10. FWE, family-wise error; MIR137, microRNA-137; MNI, Montreal Neurological Institute.
