Table 2 Inverse variance meta-analysis results at the three defined MIR137 polygene score thresholds for all participants

From: MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls

Neuropsychological variable

P=10−5

P=0.05

P=0.5

 

B

CI

B

CI

B

CI

 

Combined sample

Lower

Upper

P-value

Combined sample

Lower

Upper

P-value

Combined sample

Lower

Upper

P-value

Pre-morbid IQ (WTAR)

−42.477

−148.624

63.671

0.433

−503.302

−1165.205

158.601

0.136

−1671.986

−5226.713

1882.740

0.357

Verbal IQ

−303.427

−584.882

−21.972

0.035*

−4618.646

−7987.354

−1249.938

0.035*

−15034.193

−30768.408

700.022

0.035*

Performance IQ

−139.662

−359.382

80.059

0.213

−3515.312

−5765.215

−1265.410

0.002**

−9699.454

−17083.868

−2315.041

0.010*

Full-scale IQ

−217.145

−434.944

0.653

0.051

−3959.537

−6193.356

−1725.718

0.001**

−11042.282

−18376.914

−3707.651

0.003**

Logical memory 1

−308.570

−474.475

−142.666

0.000***

−3641.810

−5037.080

−2246.541

0.000***

−10669.811

−11909.440

−6125.766

0.000***

Logical memory 2

−221.538

−318.807

−124.269

0.000***

−2747.838

−3757.958

−1737.718

0.000***

−8330.306

−11909.440

−4751.172

0.000***

Faces 1

−94.815

−153.364

−36.267

0.002**

−1013.981

−1626.683

−401.278

0.002**

−2492.285

−4493.001

−491.569

0.002**

Faces 2

−71.837

−129.448

−14.226

0.015*

−791.795

−1394.458

−189.133

0.015*

−1534.968

−3504.421

434.485

0.015*

SWM (errors)

200.546

−45.339

446.430

0.110

3260.415

−465.077

6985.908

0.086

9254.991

91.947

18418.036

0.048*

SWM (strategy)

39.889

−45.908

−45.908

0.362

710.783

−186.172

1607.738

0.120

994.328

−1929.699

3918.354

0.505

Letter-number sequencing

−36.605

−69.831

−3.378

0.031*

−621.413

−967.522

−275.304

0.031*

−1732.880

−2867.928

−597.833

0.031*

SART reaction time

2048.904

−255.171

4352.979

0.081

19926.956

6182.706

33671.206

0.004**

45561.862

−1929.699

3918.354

0.505

CPT d’Prime 2 digit

−9.986

−26.034

6.061

0.223

−9.181

−181.359

162.997

0.917

128.901

−430.676

688.477

0.652

CPT d’Prime 3 digit

−1.246

−16.494

14.002

0.873

19.569

−142.902

182.039

0.813

243.740

−204.455

691.934

0.286

CPT d’Prime 4 digit

5.034

−7.721

17.790

0.439

46.054

−89.501

181.609

0.505

229.518

−213.062

672.099

0.309

Eyes

27.701

−39.150

94.553

0.417

−61.410

−748.152

625.332

0.861

−96.271

−2371.226

2178.684

0.934

Hint

−23.224

−80.013

33.566

0.423

−503.302

−1165.205

158.601

0.136

−1553.490

−3541.015

434.036

0.126

Externalizing bias

18.604

−30.143

67.352

0.454

194.019

−327.109

715.147

0.466

211.583

−1473.479

1896.644

0.806

Personalizing bias

−0.546

−7.551

6.458

0.878

−23.491

−97.795

50.812

0.535

−59.643

−263.523

144.236

0.566

  1. Abbreviations: CI, confidence interval; CPT, Continuous Performance Task; IQ, intelligence quotient; MIR137, microRNA-137; SART, Sustained Attention to Response Task; SWM, Spatial Working Memory; WTAR, Wechsler Test of Adult Reading.
  2. Results in bold indicate significance after correction for multiple testing across 5 cognitive domains.
  3. *P<0.05; **P<0.01; ***P<0.0001.