Table 2 Inverse variance meta-analysis results at the three defined MIR137 polygene score thresholds for all participants
Neuropsychological variable | P=10−5 | P=0.05 | P=0.5 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
B | CI | B | CI | B | CI | |||||||
Combined sample | Lower | Upper | P-value | Combined sample | Lower | Upper | P-value | Combined sample | Lower | Upper | P-value | |
Pre-morbid IQ (WTAR) | −42.477 | −148.624 | 63.671 | 0.433 | −503.302 | −1165.205 | 158.601 | 0.136 | −1671.986 | −5226.713 | 1882.740 | 0.357 |
Verbal IQ | −303.427 | −584.882 | −21.972 | 0.035* | −4618.646 | −7987.354 | −1249.938 | 0.035* | −15034.193 | −30768.408 | 700.022 | 0.035* |
Performance IQ | −139.662 | −359.382 | 80.059 | 0.213 | −3515.312 | −5765.215 | −1265.410 | 0.002** | −9699.454 | −17083.868 | −2315.041 | 0.010* |
Full-scale IQ | −217.145 | −434.944 | 0.653 | 0.051 | −3959.537 | −6193.356 | −1725.718 | 0.001** | −11042.282 | −18376.914 | −3707.651 | 0.003** |
Logical memory 1 | −308.570 | −474.475 | −142.666 | 0.000*** | −3641.810 | −5037.080 | −2246.541 | 0.000*** | −10669.811 | −11909.440 | −6125.766 | 0.000*** |
Logical memory 2 | −221.538 | −318.807 | −124.269 | 0.000*** | −2747.838 | −3757.958 | −1737.718 | 0.000*** | −8330.306 | −11909.440 | −4751.172 | 0.000*** |
Faces 1 | −94.815 | −153.364 | −36.267 | 0.002** | −1013.981 | −1626.683 | −401.278 | 0.002** | −2492.285 | −4493.001 | −491.569 | 0.002** |
Faces 2 | −71.837 | −129.448 | −14.226 | 0.015* | −791.795 | −1394.458 | −189.133 | 0.015* | −1534.968 | −3504.421 | 434.485 | 0.015* |
SWM (errors) | 200.546 | −45.339 | 446.430 | 0.110 | 3260.415 | −465.077 | 6985.908 | 0.086 | 9254.991 | 91.947 | 18418.036 | 0.048* |
SWM (strategy) | 39.889 | −45.908 | −45.908 | 0.362 | 710.783 | −186.172 | 1607.738 | 0.120 | 994.328 | −1929.699 | 3918.354 | 0.505 |
Letter-number sequencing | −36.605 | −69.831 | −3.378 | 0.031* | −621.413 | −967.522 | −275.304 | 0.031* | −1732.880 | −2867.928 | −597.833 | 0.031* |
SART reaction time | 2048.904 | −255.171 | 4352.979 | 0.081 | 19926.956 | 6182.706 | 33671.206 | 0.004** | 45561.862 | −1929.699 | 3918.354 | 0.505 |
CPT d’Prime 2 digit | −9.986 | −26.034 | 6.061 | 0.223 | −9.181 | −181.359 | 162.997 | 0.917 | 128.901 | −430.676 | 688.477 | 0.652 |
CPT d’Prime 3 digit | −1.246 | −16.494 | 14.002 | 0.873 | 19.569 | −142.902 | 182.039 | 0.813 | 243.740 | −204.455 | 691.934 | 0.286 |
CPT d’Prime 4 digit | 5.034 | −7.721 | 17.790 | 0.439 | 46.054 | −89.501 | 181.609 | 0.505 | 229.518 | −213.062 | 672.099 | 0.309 |
Eyes | 27.701 | −39.150 | 94.553 | 0.417 | −61.410 | −748.152 | 625.332 | 0.861 | −96.271 | −2371.226 | 2178.684 | 0.934 |
Hint | −23.224 | −80.013 | 33.566 | 0.423 | −503.302 | −1165.205 | 158.601 | 0.136 | −1553.490 | −3541.015 | 434.036 | 0.126 |
Externalizing bias | 18.604 | −30.143 | 67.352 | 0.454 | 194.019 | −327.109 | 715.147 | 0.466 | 211.583 | −1473.479 | 1896.644 | 0.806 |
Personalizing bias | −0.546 | −7.551 | 6.458 | 0.878 | −23.491 | −97.795 | 50.812 | 0.535 | −59.643 | −263.523 | 144.236 | 0.566 |