Table 3 Linear regression analyses of rs1702294 risk allele (C) effects on cognitive test scores for all participants

Neuropsychological variable	Standardized β	CI		P-value	r²
		Lower	Upper
IQ
Pre-morbid IQ (WTAR)	−0.044	−2.215	0.482	0.207	0.002
Verbal IQ	−0.046	−4.514	0.709	0.153	0.002
Performance IQ	−0.091	−6.701	−1.041	0.007**	0.008
Full-scale IQ	−0.080	−6.157	−0.563	0.019*	0.006
DM
Logical memory 1	−0.050	−3.077	0.298	0.106	0.003
Logical memory 2	−0.025	−1.740	0.726	0.420	0.001
Faces 1	−0.059	−1.322	0.151	0.119	0.003
Faces 2	−0.008	−0.815	0.646	0.820	0.000
WM
SWM (errors)	0.031	−1.611	4.415	0.361	0.001
SWM (strategy)	0.017	−0.800	1.316	0.632	0.000
Letter-number sequencing	−0.032	−0.642	0.202	0.306	0.001
Attention
SART reaction time	0.059	−3.873	30.073	0.013*	0.003
CPT d’Prime 2 digit	−0.044	−0.302	0.103	0.334	0.002
CPT d’Prime 3 digit	−0.031	−0.257	0.126	0.504	0.000
CPT d’Prime 4 digit	−0.019	−0.194	0.127	0.679	0.000
Social cognition
Eyes	−0.040	−1.308	0.449	0.337	0.001
Hint	−0.083	−0.972	−0.018	0.042*	0.008
Externalizing bias	0.000	−0.613	−0.614	0.998	0.000
Personalizing bias	0.020	−0.033	0.053	0.645	0.000

Abbreviations: CI, confidence interval; CPT, Continuous Performance Task; DM, declarative memory; IQ, intelligence quotient; SART, Sustained Attention to Response Task; SWM, Spatial Working Memory; WM, working memory; WTAR, Wechsler Test of Adult Reading.
Results in bold indicate significance after correction for multiple testing across 5 cognitive domains.
*P<0.05; **P<0.01; ***P<0.0001.

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