Figure 1
From: Glucose deficit triggers tau pathology and synaptic dysfunction in a tauopathy mouse model
Glucose deprivation impairs cognition in the h-tau mice. (a) Body weights (g) of 2-deoxyglucose (DG)-treated and control (CTR) mice were recorded at the beginning of the study and each month until the end when the mice were 10 months old. (b) Total number of entries and percentage of alternation in the Y-maze for controls (CTR) and h-tau mice that underwent DG treatment (DG; *P< 0.05). (c) Morris water maze test results for controls (CTR) and h-tau mice undergoing DG treatment (DG). Mice were tested initially in the cue test and then trained for 5 days to reach a platform (training phase). After the last training session, for the probe trials phase mice were put back in the water maze and the number of entries to the target platform zone as well as the distance until the first entry in the target platform zone recorded. Results are mean±s.e.m. (n=9 mice per group).
