Figure 7
From: Glucose deficit triggers tau pathology and synaptic dysfunction in a tauopathy mouse model
Glucose deprivation modulates tau phosphorylation via P38 MAPK kinase. (a) Representative western blots of total tau (HT7) and phosphorylated tau at residues S202/T205 (AT8) and S396/S404 (PHF-1) in primary cortical neuronal cells from h-tau mice incubated with normal medium (CTR) or glucose-deprived (-GLU) medium. (b) Densitometric analyses of the immunoreactivities to the antibodies shown in the previous panel (*P<0.05, **P<0.01). (c) Representative western blot analyses for P38 and pP38 in primary cortical neurons from h-tau mice incubated with normal medium (CTR) or glucose-deprived (-GLU) medium. (d) Densitometric analyses of the immunoreactivities to the antibodies shown in the previous panel (*P<0.05). Values represent mean±s.e.m.
