Figure 2 | Translational Psychiatry

Figure 2

From: Advanced brain aging: relationship with epidemiologic and genetic risk factors, and overlap with Alzheimer disease atrophy patterns

Figure 2

(a) SPARE-BA index for SHIP subjects ⩾65 years old. Values are reflecting relatively continuous progression of aging-related atrophy patterns with age. Based on SPARE-BA, we grouped these subjects into subjects with advanced brain aging (red dots; 0.5 s.d. below trend line) and resilient to brain aging (black triangles; 0.5 s.d. above trend line). (b) The relationship between age and SPARE-AD (reflecting clinical AD-like patterns of brain atrophy) in both groups. Advanced brain aging individuals have higher SPARE-AD values. SPARE-AD, Spatial Patterns of Abnormality for Recognition of Early Alzheimer’s Disease; SPARE-BA, Spatial Pattern of Atrophy for Recognition of BA.

Back to article page