Figure 4 | Translational Psychiatry

Figure 4

From: Advanced brain aging: relationship with epidemiologic and genetic risk factors, and overlap with Alzheimer disease atrophy patterns

Figure 4

Patterns overlap. Blue: regions displaying significant regional atrophy patterns between resilient and ABA individuals; Red: regions displaying significantly AD-related patterns of atrophy in high vs low SPARE-AD individuals; Green: overlap of the blue and red regions (P<0.001 and FDR correction with q<0.001). Histograms are presented for gray matter volumes of blue/red/green regions for ABA and RA individuals. These results highlight the difference between advanced and clinical AD-like brain aging, and they also indicate that increased SPARE-AD values in advanced aging are entirely due to partial overlap (green) of underlying regions. ABA, advanced brain aging; FDR, false discovery rate; RA, resilient to aging; SPARE-AD, Spatial Patterns of Abnormality for Recognition of Early Alzheimer’s Disease.

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