Figure 1 | Translational Psychiatry

Figure 1

From: Financial difficulties but not other types of recent negative life events show strong interactions with 5-HTTLPR genotype in the development of depressive symptoms

Figure 1

Linear regression analysis indicated a significant interaction effect between the 5-HTTLPR genotype and specific types of recent life events on current depression scores in the total population and subpopulations. Recent life events are categorised as 0 (no recent life events reported), 1 (1 life event reported) and 2 or more life events reported in the last year. s.e.m. is displayed. Linear regression indicated a significant interaction between the 5-HTTLPR genotype and recent life events related to illness and injury (RLE-illness) on current depression scores in the combined (Budapest+Manchester) sample according to the additive (P=0.016, FDR q=0.038) and dominant (P=0.009, FDR q=0.035) models (a); a significant interaction effect between the 5-HTTLPR genotype and recent life events related to financial difficulties in the last year (RLE-financial) on current depression scores in the combined (Budapest+Manchester) sample according to additive (P=0.017, FDR q=0.038) and recessive models (P=0.002, FDR q=0.016) (b); a significant interaction effect between the 5-HTTLPR genotype and recent life events related to financial difficulties in the last year (RLE-financial) on current depression scores in the Budapest sample according to additive (P=0.007, FDR q=0.035) and recessive models (P=0.001, FDR q=0.012) (c); and a significant interaction effect between the 5-HTTLPR genotype and recent life events related to financial difficulties in the last year (RLE-financial) in the Manchester sample on current depression scores according to the recessive model (P=0.00997, FDR q=0.035) (d). The increasing number of s alleles increases current depression score with the increasing number of recent life events related to illness and injury (a) or financial difficulties according to the additive model (b, c), and current depression score increases with the increasing number of recent life events related to financial difficulties in those carrying the ss genotype according to the recessive model (d). FDR, false discovery rate.

Back to article page