Table 2 Main effect and interactions of the 5-HTTLPR polymorphism on depression symptoms in the combined population sample of Budapest and Manchester

From: Financial difficulties but not other types of recent negative life events show strong interactions with 5-HTTLPR genotype in the development of depressive symptoms

Combined sample

ADD

DOM

REC

5-HTTLPR polymorphism

β

s.d.

P

FDR Q

β

s.d.

P

FDR Q

β

s.d.

P

FDR Q

Main effect

0.0099

0.0278

0.7205

0.2522

0.0070

0.0414

0.8674

0.2860

0.0225

0.0504

0.6556§

0.2390

Interaction with RLE

0.0446

0.0287

0.0327

0.0606

0.0455

0.0306

0.1370

0.1152

0.0798

0.0384

0.0381

0.0606

Interaction with RLE-relationship

0.1001

0.0726

0.1684

0.1340

0.1329

0.1074

0.2160

0.1350

0.1341

0.1338

0.3164

0.1579

Interaction with RLE-financial

0.1208

0.0506

0.0172 §

0.0375

0.0777

0.0760

0.3067

0.1579

0.2899

0.0927

0.0018 §*

0.0156

Interaction with RLE-illness

0.1070

0.0442

0.0156

0.0375

0.1711

0.0653

0.0088

0.0349

0.0979

0.0816

0.2304

0.1377

Interaction with RLE-social

−0.0362

0.0444

0.4143

0.1774

−0.0245

0.0641

0.7021

0.2508

−0.0872

0.0843

0.3010

0.1579

  1. Abbreviations: ADD, additive model; DOM, dominant model; FDR, false discovery rate; REC, recessive model; RLE, recent life stress; RLE-financial, financial difficulties; RLE-relationship, intimate relationship problems; RLE-illness, illness/injury; RLE-social, social network disturbances.
  2. Bold type denotes significant (P<0.05) values; bold italics indicates significant P-values surviving correction for multiple testing (P<0.05, FDR q<0.05). Effects replicated (signifcant after correction) in the Budapest (§) and Manchester (*) samples are also marked.
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