Table 3 Main effect and interactions of the 5-HTTLPR polymorphism on depression symptoms in the population sample of Budapest

From: Financial difficulties but not other types of recent negative life events show strong interactions with 5-HTTLPR genotype in the development of depressive symptoms

Budapest sample

ADD

DOM

REC

5-HTTLPR polymorphism

β

s.d.

P

FDR Q

β

s.d.

P

FDR Q

β

s.d.

P

FDR Q

Main effect

0.0645

0.0328

0.0497

0.0669

0.0445

0.0485

0.3589

0.1653

0.1503

0.0606

0.0133

0.0375

Interaction with RLE

0.0457

0.0269

0.0899

0.0968

0.0523

0.0394

0.1850

0.1349

0.0796

0.0504

0.1146

0.1114

Interaction with RLE-relationship

0.0517

0.0857

0.5466

0.2087

0.0183

0.1237

0.8826

0.2860

0.1610

0.1634

0.3248

0.1579

Interaction with RLE-financial

0.1916

0.0701

0.0070

0.0349

0.1416

0.1122

0.2074

0.1350

0.4320

0.1263

0.0007

0.0115

Interaction with RLE-illness

0.0884

0.0518

0.0887

0.0968

0.1574

0.0751

0.0365

0.0606

0.0590

0.1009

0.5587

0.2087

Interaction with RLE-social

−0.0311

0.0534

0.5604

0.2087

0.0120

0.0761

0.8749

0.2860

−0.1259

0.1016

0.2156

0.1350

  1. Abbreviations: ADD, additive model; DOM, dominant model; FDR, false discovery rate; REC, recessive model; RLE, recent life stress; RLE-financial, financial difficulties; RLE-illness, illness/injury; RLE-relationship, intimate relationship problems; RLE-social, social network disturbances.
  2. Bold type denotes significant (P<0.05) values; bold italics indicate significant P-values surviving correction for multiple testing (P<0.05, FDR q<0.05).
Back to article page