Table 4 Main effect and interactions of the 5-HTTLPR polymorphism on depression symptoms in the population sample of Manchester

From: Financial difficulties but not other types of recent negative life events show strong interactions with 5-HTTLPR genotype in the development of depressive symptoms

Manchester sample

ADD

DOM

REC

5-HTTLPR polymorphism

β

s.d.

P

FDR Q

β

s.d.

P

FDR Q

β

s.d.

P

FDR Q

Main effect

−0.0442

0.0388

0.2538

0.1433

−0.0422

0.0584

0.4701

0.1959

−0.082

0.0694

0.2361

0.1377

Interaction with RLE

0.0470

0.0280

0.0941

0.0968

0.0396

0.0411

0.3354

0.1586

0.0942

0.0513

0.0662

0.0828

Interaction with RLE-relationship

0.1373

0.1018

0.1776

0.1349

0.2303

0.1532

0.1331

0.1152

0.1124

0.1833

0.5398

0.2087

Interaction with RLE-financial

0.1308

0.0661

0.0480

0.0669

0.0819

0.0977

0.4024

0.1774

0.3148

0.1220

0.0010

0.0349

Interaction with RLE-illness

0.0929

0.0626

0.1382

0.1152

0.1212

0.0941

0.1978

0.1350

0.1240

0.1114

0.2656

0.1453

Interaction with RLE-social

−0.0392

0.0611

0.5214

0.2087

−0.0296

0.0892

0.7403

0.2540

−0.0943

0.1159

0.4157

0.1774

  1. Abbreviations: ADD, additive model; DOM, dominant model; FDR, false discovery rate; REC, recessive model; RLE, recent life stress; RLE-financial, financial difficulties; RLE-illness, illness/injury; RLE-relationship, intimate relationship problems; RLE-social, social network disturbances.
  2. Bold type denotes significant (P<0.05) values; bold italics indicates significant P-values surviving correction for multiple testing (P<0.05, FDR q<0.05).
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