Figure 1 | Translational Psychiatry

Figure 1

From: HPA-axis function and grey matter volume reductions: imaging the diathesis-stress model in individuals at ultra-high risk of psychosis

Figure 1

Method used to include a priori biological information. We used data from the Allen Brain Atlas (Allen Brain Atlas methodology summarized in (a–c) and described in detail in ref. 18) to create a new brain mask (d) used to flexibly threshold our results according to the expression of cortisol-binding receptors. (a) Information about expression levels of glucocorticoid (GR) and mineralocorticoid (MR) receptors was obtained from several parts of the brain of six healthy adults from the Allen Brain Atlas. (b) Samples obtained from the same region of interest of the template used were averaged. (c) Expression rates of probes targeting the same gene (MR or GR) were averaged. (d) Brain mask ranking regions according to their average expression of glucocorticoid and mineralocorticoid receptors in the healthy brain. The brain is shown in radiological convention (where the left side of the figure is the right side of the brain).

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