Table 3 Relationship of present findings to analyses of archival data sets

From: Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment

 

MDD versus control

 

Observed

GSE38206

GSE36957

Relationship a

CREB

2.66±0.20, P=0.0007b

1.23±0.03, P<0.0001b

1.55±0.08, P<0.0001b

Consistent

ISRE

1.46±0.39, P=0.3091

1.81±0.17, P=0.0003b

1.46±0.23, P=0.0030b

Additional

NRF2

2.11±0.18, P=0.0019b

1.42±0.05, P<0.0001b

1.06±0.04, P=0.0593

Partially consistent

NF-κB

0.92±0.03, P=0.0480

1.06±0.03, P=0.0016b

1.29±0.09, P<0.0001b

Additional

GR

1.05±0.06, P=0.4198

0.84±0.07, P=0.0033b

0.83±0.10, P=0.0657

Null

EGR1

1.10±0.10, P=0.4216

1.59±0.13, P=0.0010b

1.07±0.03, P=0.2893

Null

EGR2

0.42±0.23, P=0.0140

1.96±0.24, P=0.0004b

0.98±0.05, P=0.6717

Null

EGR3

0.41±0.43, P=0.0665

1.75±0.14, P=0.0002b

1.04±0.09, P=0.4854

Null

EGR4/NGFIC

0.53±0.36, P=0.1113

1.78±0.18, P=0.0008b

1.21±0.23, P=0.0629

Null

  1. Abbreviations: CREB, cAMP response element-binding; EGR, early growth response; GR, glucocorticoid receptor; ISRE, interferon-stimulated response element; MDD, major depressive disorder; NF-κB, nuclear factor kappa-B; NRF2, nuclear factor erythroid-derived 2-like 2; TFBM, transcription factor-binding motif.
  2. Values represent the mean fold difference in promoter TFBM distribution±s.e., and two-tailed P-value testing null hypothesis 1.0-fold.
  3. aConsistent, archival studies are consistent and are in concordance with results of present MDD versus control comparison; Additional, archival studies are consistent, but relationship is not detected in present sample; Partially consistent, archival studies are inconsistent, but one is in concordance with present MDD versus Control comparison; Null, archival studies are inconsistent.
  4. bStatistically significant under Bonferroni correction for simultaneous testing of nine pathways (individual P<0.0056).
Back to article page