Table 2 CSF levels of amino acids and ratio of amino acids in subjects at baseline

From: Abnormality in glutamine–glutamate cycle in the cerebrospinal fluid of cognitively intact elderly individuals with major depressive disorder: a 3-year follow-up study

Characteristic

Comparison group at baseline (N=19)

MDD group at baseline (N=28)

 

Analysis

 
   

t

df

P

Glutamine

568.17±81.19

591.04±87.78

0.903

45

0.371

Glutamate

0.647±0.82

0.382±0.11

1.407

18.5a

0.176

Glycine

12.99±5.95

11.38±2.67

1.103

23.0a

0.282

l-Serine

25.45±5.58

22.36±5.13

1.955

45

0.057

d-Serine

1.76±0.38

1.75±0.43

0.093

45

0.926

Glutamine/glutamate

1257.6±458.4

1645.6±434.7

2.938

45

0.005 b

Glycine/l-serine

0.496±0.14

0.526±0.14

0.7

45

0.488

d-Serine/l-serine

0.072±0.021

0.080±0.019

1.326

45

0.192

  1. Abbreviations: CSF, cerebrospinal fluid; df, degrees of freedom; MDD, major depressive disorder.
  2. Bold P-values indicate statistically significant. The data are mean±s.d.
  3. aEquality of variance assumption not met.
  4. bDenotes significant finding at α=0.006 after Sidak’s adjustment (eight tests).
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