Figure 1

22q11DS COMT Met carriers have reduced cortical thickness compared with Val carriers only after puberty and especially in females. (a) A significant reduction of cortical thickness in 22q11DS Met carriers was observed compared with Val carriers in post-puberty. There were no clusters of greater thickness in Met compared with Val carriers. (b) Mean cortical thickness values for the clusters 1 to 6 are reported in the plots. (1=left precentral/inferior middle frontal cortices, 2=left superior frontal cortex, 3=right superior frontal cortex, 4=right medial superior frontal cortex, 5=precuneus, 6=posterior fusiform gyrus). Post-pubertal: COMT Val N=34; COMT Met N=36. *P<0.05 and **P<0.01 versus 22q11DS Val carriers. (c) When considering only females post-pubertal patients, a significant reduction of cortical thickness in 22q11DS Met carriers compared with Val carriers was similarly observed. Cortical thickness did not significantly differ in male patients carrying the Met and Val COMT allele. (d) The plots represent mean cortical thickness values in female patients for each cluster. (1=left superior frontal cortex, 2=left inferior frontal/insula/superior temporal cortices, 3=left occipital cortex, 4=left supramarginal gyrus, 5= left medial superior frontal cortex, 6=right inferior frontal cortex, 7=right medial superior frontal/anterior cingulate cortices, 8=right precuneus, 9=right posterior fusiform gyrus/lateral occipital cortex).*P<0.05 and **P<0.01 versus 22q11DS Val carriers.