Figure 5
From: Adolescence is the starting point of sex-dichotomous COMT genetic effects
COMT sexually divergent effects on cognitive functions are evident from adolescence in both mice and human patients with 22q11DS. Discrimination index displayed by (a) adolescent and (b) adult COMT+/+, +/− and −/− males and females littermates mice during the 5 min temporal order object recognition test. Pubertal COMT+/+ males N=12, females, N=14; COMT+/− males N=17, females N=12; COMT−/− males N=6, females N=6. Post-pubertal COMT+/+ males N=16, females, N=11; COMT+/− males N=11, females N=18; COMT−/− males N=9, females N=8. *P<0.05 and **P<0.005 versus chance levels. (c) Number of errors made during the Wisconsin Card Sorting test (WCST) by subjects affected by 22q11DS divided by their sex (males or females), and COMT genotype (Val or Met). COMT Val males N=22, females, N=12; COMT Met males N=20, females N=12. *P<0.05 versus all other groups.
