Figure 3 | Translational Psychiatry

Figure 3

From: Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

Figure 3

Polygenic risk score analysis. The proportion of variance explained in case–control status (y axis; Nagelkerke’s R2) by the PRS for BIP, SCZ and MDD is depicted for the different P-value cutoffs used in the calculation of the PRS. Principal components were included in the models to control for population stratification. 1*, P<0.05; 2*, P<0.001; 3*, P<1 × 10−4; 4*, P<1 × 10−6; 5*, P<1 × 10−8; 6*, P<1 × 10−10; 7*, P<1 × 10−12. BIP, bipolar disorder; MDD, major depressive disorder; NS, nonsignificant; PRS, polygenic risk score; SCZ, schizophrenia.

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