Figure 4 | Translational Psychiatry

Figure 4

From: Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

Figure 4

Polygenic risk score analysis in subgroups. Mean z-standardized PRS and standard error (s.e.) for BIP, SCZ and MDD are shown in the control group, all cases, and in cases with and without comorbid MDD. PRS with a P-value threshold of P=0.05 were selected for this comparison and principal components were included in the models to control for population stratification. The numbers at the top of each bar indicate the significance of the difference in the respective PRS in comparison with the control group. 1*, P<0.05; 2*, P<0.001; 3*, P<1 × 10−4; 4*, P<1 × 10−6; 5*, P<1 × 10−8; 6*, P<1 × 10−10; 7*, P<1 × 10−12. BIP, bipolar disorder; BOR, borderline personality disorder; MDD, major depressive disorder; NS, nonsignificant; PRS, polygenic risk score; SCZ, schizophrenia.

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