Table 1 Comparison of CpG sites mapping to reported genes in PTSD and MDD literatures

From: An epigenome-wide DNA methylation study of PTSD and depression in World Trade Center responders

Gene

PTSD

MDD

 

N

Hypo

Hyper

N

Hypo

Hyper

Reference

FKBP5

1

1

0

1

1

0

Binder et al.12 Klengel et al.13 Weder et al.32

NR3C1

1

1

0

6

6

0

McGowan et al.10 Yehuda et al.11 Weder et al.32

BDNF

4

3

1

2

2

0

Roth et al.16 Weder et al.32

SLC6A4

0

0

0

1

1

0

Chang et al.14 Koenen et al.15

TPR

0

0

0

0

0

0

Smith et al.26

CLEC9A

0

0

0

0

0

0

Smith et al.26

ANAPC5

0

0

0

0

0

0

Smith et al.26

ANXA2

1

1

0

2

2

0

Smith et al.26

TLR8

1

0

1

0

0

0

Smith et al.26

GRIK2

0

0

0

2

2

0

Nagy et al.31

BEGAIN

0

0

0

0

0

0

Nagy et al.31

GRIN1

0

0

0

2

0

2

Weder et al.32

ID3

0

0

0

0

0

0

Weder et al.32

TPPP

0

0

0

2

0

2

Weder et al.32

ADCYAP1

3

2

1

2

2

0

Ressler et al.17

  1. Abbreviations: Hyper, hypermethylation in case relative to control; Hypo, hypomethylation in case relative to control; MDD, major depressive disorder; PTSD, posttraumatic stress disorder. N, number of CpG sites at nominal P0.05.